Patients and Medical Professionals
Dispensing errors have been reported between TOPAMAX® (topiramate)
tablets and TOPROL-XL® (metoprolol succinate) extended-release
Please be sure to check your tablets to ensure you are taking the right medicine.
*TOPROL-XL is a registered trademark of the AstraZeneca group of companies.
TOPAMAX® is approved for migraine prevention in adults only.
TOPAMAX® is not used to stop a migraine after it starts.
IMPORTANT SAFETY INFORMATION
Warnings and Precautions
may cause eye problems. Serious eye problems include:
sudden decrease in vision with or without eye pain and redness; blockage of fluid
in the eye causing increased pressure in the eye (secondary angle closure glaucoma).
These eye problems can lead to permanent loss of vision if not treated. You should
call your healthcare professional right away if you have any new eye symptoms.
may cause decreased sweating and increased body
temperature (fever). People, especially children, should be watched for signs of
decreased sweating and fever, especially in hot temperatures. Some people may need
to be hospitalized for this condition. Call your healthcare provider right away
if you have a high fever, a fever that does not go away, or decreased sweating.
can increase the level of acid in your blood (metabolic
acidosis). If left untreated, metabolic acidosis can cause brittle or soft bones
(osteoporosis, osteomalacia, osteopenia), kidney stones, can slow the rate of growth
in children, and may possibly harm your baby if you are pregnant. Metabolic acidosis
can happen with or without symptoms. Sometimes people with metabolic acidosis will:
feel tired, not feel hungry (loss of appetite), feel changes in heartbeat, or have
trouble thinking clearly. Your healthcare provider should do a blood test to measure
the level of acid in your blood before and during your treatment with TOPAMAX®
. If you are pregnant, you should talk to your healthcare
provider about whether you have metabolic acidosis.
Like other antiepileptic drugs, TOPAMAX®
may cause suicidal
thoughts or actions in a very small number of people, about 1 in 500. Pay attention
to any changes and call your doctor right away if you have any of these symptoms,
especially if they are new, worse, or worry you: thoughts about suicide or dying,
attempts to commit suicide, new or worse depression, new or worse anxiety, feeling
agitated or restless, panic attacks, trouble sleeping (insomnia), new or worse irritability,
acting aggressive, being angry or violent, acting on dangerous impulses, an extreme
increase in activity and talking (mania), or other unusual changes in behavior or
may affect how you think, and cause confusion, problems
with concentration, attention, memory, or speech, depression or mood problems, tiredness,
and sleepiness. Do not stop taking TOPAMAX®
talking to your doctor. Stopping TOPAMAX®
suddenly can cause
If you take TOPAMAX®
during pregnancy, your baby has a higher
risk for birth defects called cleft lip and cleft palate. These defects can begin
early in pregnancy, even before you know you are pregnant. There may be other medicines
to treat your condition that have a lower chance of birth defects. All women of
childbearing age should talk to their healthcare providers about using other possible
treatments instead of TOPAMAX®
. If the decision is made to
, you should use effective birth control (contraception)
unless you are planning to become pregnant. Tell your healthcare provider right
away if you become pregnant while taking TOPAMAX®
. You and
your healthcare provider should decide if you will continue to take TOPAMAX®
while you are pregnant. Metabolic acidosis may have harmful effects on your baby.
Talk to your healthcare provider if TOPAMAX®
has caused metabolic
acidosis during your pregnancy. If you become pregnant while taking TOPAMAX®
talk to your healthcare provider about registering with the North American Antiepileptic
Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334.
The purpose of this registry is to collect information about the safety of antiepileptic
drugs during pregnancy.
may cause high blood ammonia levels. High ammonia
in the blood can affect your mental activities, slow your alertness, make you feel
tired, or cause vomiting.
when you are also taking valproic acid can
cause a drop in body temperature (hypothermia) to less than 95ºF, feeling tired,
confusion, or coma.
The most common side effects of TOPAMAX®
in arms and legs, loss of appetite, nausea, taste change, diarrhea, weight loss,
nervousness, and upper respiratory tract infection.
Tell your doctor about other medications that you are taking. Report any side effect
that bothers you or that does not go away.
These are not all the possible side effects of TOPAMAX®
For more information, ask your healthcare professional or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch
, or call 1-800-FDA-1088.
Please see full US
Prescribing Information and Medication Guide